Piloting and Scale-up

Scale with Confidence

Piloting is a critical phase in the path to commercialization, enabling us to integrate the full process, fine-tune parameters, refine operations, and reduce risks before entering production. It also enables production of product samples for quality testing, regulatory submissions, and application development. Our two pilot plants in Emeryville, CA and Campinas, Brazil, coupled with a strong network of trusted CROs, speed new product prototyping and facilitate scale-up around the world.
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fermentation-based molecules purified at 1 kg scale or above
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fermentation-based molecules produced at commercial scale
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technology transfers completed to facilities around the world

Emeryville Pilot Plant

At our Food-grade compliant, Kosher certified Pilot facility in Emeryville, we focus on rapid technology development and delivery of kilogram-scale samples that accurately represent full-scale production quality.
The facility is equipped with a wide range of unit operations, including:
  • 1000L fermenter and multiple 20L and 300L fermenters
  • Feedstock sterilization 
  • L/S and L/L centrifugation 
  • Homogenization 
  • Solvent extraction 
  • Normal and Tangential Flow filtration 
  • Wiped film evaporation / distillation 
  • Chromatography 
  • Drying

Campinas Pilot Plant

With a pilot plant infrastructure that mirrors industrial conditions, we generate the data and insights required for a successful transition to production. At our Campinas Pilot Plant, we focus on rapid deployment and optimization of processes for full-scale manufacturing. Proximity to our manufacturing plant in Barra Bonita and external manufacturing partners ensures real-time transfer of knowledge from piloting to manufacturing and back, translating lab-scale concepts into scalable and robust processes.

Tech Transfer

Our tech transfer capability is built to ensure that every innovation developed in the pilot plant reaches manufacturing with exceptional fidelity. Through a collaborative approach between process development and manufacturing operations, we rigorously evaluate critical process parameters, optimize scalability, and design robust control strategies. Every stage, from raw material preparation to product release, is treated as a learning opportunity. These insights are systematically captured and embedded into our methodologies, driving continuous improvement and reinforcing the robustness of our tech transfer processes.

Our seasoned team will enable you to innovate with confidence, de-risk decisions, and deliver market-ready solutions

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